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Clinical Trial 1 using a natural IBS treatment

IBS SYMPTOM RELIEF using a natural IBS treatment: THE EFFECTIVENESS OF NUCLEOTIDE SUPPLEMENT IN THE MANAGEMENT OF INDIVIDUALS WITH IRRITABLE BOWEL SYNDROME

Pilot trial conducted in 2003.

KGK Inc., London, Ontario, Canada with the University of Guelph; J. Conquer, Phd

Subjects and Methods of IBS symptom relief using a natural IBS treatment.

The study was conducted as a randomized two-period crossover trial. Male and female volunteers with IBS were recruited for the study.

After signing a letter of consent, subjects were assigned, in a random order, to receive nucleotide supplement (IntestaidIB) or placebo, two capsules, two times per day, for a period of six weeks. After that, the second supplement was given for another six weeks period.

SUMMARY AND CONCLUSIONS

This pilot study was designed to determine whether in a group of 15 patients with diarrhea-predominant IBS, dietary supplementation with IntestaidIB could alter IBS symptoms and/or quality of life.

The results indicate that the administration of IntestaidIB decreased straining, hard stool and incomplete evacuation in individuals with IBS without causing any adverse effects.

In addition, IntestaidIB intake reduced a number of days with reported straining, flatulence and incomplete evacuation. The above improvements were generally observed after only 4-6 weeks of treatment. The nucleotide intake also tended to improve almost all other symptoms of IBS, especially mucus and urgency, but these effects were not statistically significant, most likely or partially due to the following variables:

A low number of study participants
Inability to monitor accurate and consistent dosing
Variables in individual lifestyles and dietary habits
Length and severity of chronic diarrhea related to diagnosed IBS
Short term therapy
Insufficient supplementation of active ingredient (dietary nucleotides)

Overall, the results are encouraging and are being verified in a larger group of IBS patients by Prof. Christine Dancey at the University of East London.