Clinical Trial 2 using the natural remedy for IBS, IntestAid
A NATURAL REMEDY FOR IBS: THE EFFECTIVENESS OF NUCLEOTIDE SUPPLEMENT, INTESTAID IB, IN THE MANAGEMENT OF INDIVIDUALS WITH IRRITABLE BOWEL SYNDROME
Clinical trial conducted in 2004/5.
University of East London, Prof. Christine Dancey.
Irritable Bowel Syndrome is a chronic disorder of unknown aetiology, and for which treatments are less than effective. This double-blind randomised cross-over placebo study tested whether treatment of IB symptoms were improved by IntestAidB, which is a food supplement based on RNA dietary nucleotides. Nucleotides play key roles in many biological processes. The requirements for nucleotides may increase when recovering from major tissue injury, systemic infection or possibly when liver function is suppressed. Thirty-seven people with a confirmed diagnosis of IBS completed symptom diaries for a baseline period of 28 days followed by 56 days of the experimental condition and placebo condition, with a four-week washout period during conditions. Participants rated severity of seven symptoms every day. Interrupted time-series analyses were carried out for the following symptoms: abdominal pain, diarrhoea, urgency to have a bowel movement, a feeling of incomplete evacuation, flatulence, bloating and constipation. Time series evaluates the impact of the intervention(s), taking into account the patterns in the data at baseline.
All symptoms were improved to a greater extent for participants taking IntestAidIB
as compared to placebo. The percentage of participants who showed a significant response
to the placebo condition varied from 13.9% to 35.1%.
Symptoms that were
significantly improved by IntestAidIB were Abdominal pain, Urgency, and Feelings of Incomplete evacuation.
Overall the average % of patients improved was 23.73% for participants on IntestAidIB.
Furthermore, there was a tendency for abdominal pain and incomplete evacuation to reduce over the
eight-week experimental period.
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